論文種別 原著(症例報告除く)
言語種別 英語
査読の有無 その他(不明)
表題 Factors associated with marked reduction in tongue pressure in patients with esophageal cancer during neoadjuvant chemotherapy.
掲載誌名 正式名：Esophagus : official journal of the Japan Esophageal Society
略　 称：Esophagus
ISSNコード：16129067/16129059
掲載区分国外
巻・号・頁 pp.Online ahead of print
著者・共著者 Takuya Fukushima, Makoto Yamasaki, Nobuyuki Yamamoto, Yasuaki Arima, Taisei Ashida, Shuta Takaishi, Hanako Koda, Satoshi Toshiyama, Takashi Harino, Yuki Hashimoto, Masaya Kotsuka, Takuji Sato, Kentaro Inoue, Kimitaka Hase, Jiro Nakano
発行年月 2026/08
概要 BACKGROUND:Tongue pressure is a predictor of postoperative aspiration. This study aimed to examine changes in tongue pressure during neoadjuvant chemotherapy (NAC), identify associated factors, and investigate whether these changes are related to other functional outcomes, including exercise capacity and muscle function.METHODS:This prospective, single-center, observational study enrolled 68 patients with esophageal cancer scheduled to undergo NAC. Patients were classified into marked reduction (n=17) and remaining (n=51) groups based on the rate of change in tongue pressure. Tongue pressure, muscle function, walking ability, and exercise capacity were evaluated before and after NAC. Multivariate logistic regression analysis was performed to identify the factors significantly associated with a marked reduction in tongue pressure. Spearman's correlation analysis was used to evaluate the relationships between the rate of change in tongue pressure and the rates of change in each functional parameter.RESULTS:Multivariable logistic regression analysis identified age and the number of days during NAC when oral intake was not possible as significant independent factors associated with a marked reduction in tongue pressure. Spearman's correlation analysis revealed no significant correlations between the rate of change in tongue pressure during NAC and the rates of change in handgrip strength, isometric knee extensor strength, 30-s chair stand test performance, quadriceps thickness, maximum inspiratory pressure, maximum expiratory pressure, 10-m walk test result, or 6-min walk distance.CONCLUSIONS:These findings underscore the importance of incorporating swallowing function, including tongue pressure, into prehabilitation programs.
DOI 10.1007/s10388-026-01246-8
PMID 42671683